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Detection of Antibiotic Resistant Using Microfluidics

Antibiotic resistance in superbugs is a major threat to global public health. As a result, there is a growing need for methods and technologies that enable rapid antibiotic resistance detection. In the face of the continuous evolution of antibiotic-resistant bacteria, new detection methods are urgently needed. Microfluidic technologies may be an alternative to common low-throughput antibiotic resistance tests and may open new avenues for antibiotic resistance studies at the population and single-cell levels.

Ace Infectious aims to provide currently implemented or develop emerging microfluidic technologies to rapidly detect antibiotic resistance.

Microfluidics for Rapid Diagnostics

The use of microfluidic diagnostic techniques is a promising tool in many areas such as clinical diagnostics, food safety and environmental monitoring. Recently, microfluidics has also been applied to the detection of antibiotic-resistant bacteria. Compared to traditional assays, microfluidics embodies advantages such as rapid and high-throughput analysis, low cost, smaller sample size, automation, and portability.

Like traditional methods, microfluidic-based antibiotic resistance assays can be divided into two main categories: genotypic and phenotypic. Genotypic microfluidic assays target genetic markers, thus avoiding tedious processes such as bacterial growth. Phenotypic microfluidic assays monitor bacterial growth in the presence of antibiotics, thus providing accurate antibiotic resistance results.

Microfluidics for Rapid Diagnostics

Our Detection Services of Antibiotic Resistant

We offer and develop various microfluidic devices to detect antibiotic resistance. Our services may include experimenting with different forms of microfluidic technology such as active microfluidics, droplet microfluidics, paper microfluidics and capillary driven microfluidics to design and develop devices for rapid bacterial resistance testing. Based on our proven microfluidic technologies, our services can provide you with powerful tools for antibiotic resistance diagnosis.

We can develop appropriate strategies by the implication of microfluidics as a smart choice for antibiotic resistance detection. The large surface area to volume ratio of microfluidic chips provides simple, robust, cost effective and portable diagnostics for bacterial samples.

You can choose from a variety of methods based on which to implement bacterial detection using microfluidic platforms. The methods we offer include, but are not limited to,

  • Spectroscopy-based approaches
  • Colorimetric-based approaches
  • pH-based approaches.
  • Quartz-crystal microbalance (QCM)-based approaches
  • Single-cell or single-molecule approaches
  • Multiplex approaches

Key Issues in Addressing Bacterial Resistance Detection Using Microfluidics

  • Learn more about superbugs. We are able to precisely control the local environment, narrow the analysis and manipulate the spatial distribution of cells based on microfluidics, helping researchers to study the mechanisms and physiological processes associated with bacterial and antibiotic resistance, thus pointing to new targets for drug development and resistance control.
  • Better antibiotic resistance testing. We use microfluidics to develop new assay tools that offer significant advantages over traditional and many emerging technologies. These systems are capable of performing high-throughput testing in significantly shorter timeframes and are reliable in terms of accuracy and stability.
  • Development of new antibiotics. After identifying new targets, we can use microfluidics to develop new antibiotics by expanding the search for new compounds while increasing efficiency and reducing development costs.

Ace Infectious focuses on the development of the field of microfluidics for rapid bacterial resistance detection and works to exploit the potential of microfluidics in addressing antibiotic resistance. You can contact us at any time for any of your research needs.

References

  1. Kaprou G D, et al. Rapid Methods for Antimicrobial Resistance Diagnostics. Antibiotics, 2021, 10, 209.
  2. Liu Z, et al. Microfluidics for combating antimicrobial resistance. Trends in biotechnology, 2017, 35(12): 1129-1139.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
Get in touch with our team immediately.