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Therapies Development Targeting Two-Component Regulatory System of A. Baumannii

A. baumannii is notorious for its high level of antibiotic resistance, and the emergence of multidrug-resistant strains has become a global threat. The two-component regulatory system (TCS) of A. baumannii plays a crucial role in its virulence and antibiotic resistance, making it a promising target for therapy development. Ace Infectious offers development services targeting TCS of A. baumannii to combat this superbug.

TCS of A. Baumannii

The TCS of A. baumannii is a sophisticated system composed of a membrane-bound sensor kinase (SK) and a cytoplasmic response regulator (RR). The SK detects environmental signals and transmits them to the RR, which modulates gene expression to adapt to changes in the environment. A. baumannii has over 70 putative TCSs, making it a complex regulatory system.

The known roles of two-component regulatory systems in antimicrobial resistance.Fig. 1 The known roles of two-component regulatory systems in antimicrobial resistance. (Bhagirath A Y, et al., 2019)

Studies have shown that TCS plays a crucial role in A. baumannii's virulence and antibiotic resistance.

Our Development Services

We offer development services targeting TCS of A. baumannii to identify and develop therapies that can effectively disrupt the TCS and thereby reduce the virulence and antibiotic resistance of this superbug. Our services include the following:

  • We use a variety of approaches, including genome analysis and bioinformatics, to identify potential TCS targets in A. baumannii.
  • We use high-throughput screening assays to identify compounds that can modulate the activity of the TCS targets, and animal models of A. baumannii infection to validate the efficacy of the compounds in vivo.
  • We use medicinal chemistry and structure-activity relationship (SAR) studies to optimize the lead compounds for improved potency and selectivity.

Several Strategies Targeting A. Baumannii's TCS

We use several strategies to target the TCS of A. baumannii, including the following:

  • Targeting SK
  • Targeting RR

We can provide antisense oligonucleotides (ASO), phage therapy and many other forms.

  • ASOs can bind to complementary mRNA molecules and block their translation. We use ASO to target the mRNAs of TCS components, thereby reducing TCS expression.
  • We develop phage cocktails to target the TCS of A. baumannii and reduce its virulence and antibiotic resistance.

Service Features

We pride ourselves on providing comprehensive and customized development services to meet the needs of our clients. Our development services offer the following features.

  • Expertise
  • Customization
  • High-quality data
  • Flexibility
  • Confidentiality

The TCS of A. baumannii plays a crucial role in its virulence and antibiotic resistance, making it a promising target for therapy development. Ace Infectious offers comprehensive development services targeting the TCS of A. baumannii, using a range of strategies to identify and optimize compounds that can disrupt the TCS and reduce the virulence and antibiotic resistance of this superbug.

We are committed to working with our clients to develop effective therapies that can address this global health threat. Don't hesitate to contact us.

References

  1. Bhagirath A Y, et al. Two component regulatory systems and antibiotic resistance in Gram-negative pathogens. International journal of molecular sciences, 2019, 20(7): 1781.
  2. Kumar A, et al. Bioinformatics analysis of two component (TC) systems in Acinetobacter baumannii: an extensive genomic and transcriptomic survey. BMC Genomics, 2015;16(1):554.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
Get in touch with our team immediately.