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Vaccine Development Targeting Antibiotic-Resistant Genes of Superbugs

Ace Infectious is a leading provider of vaccine development services targeting antibiotic-resistant genes of superbugs. With the emergence of antibiotic-resistant superbugs, there is an urgent need to develop alternative strategies for treating these infections. Vaccines targeting antibiotic-resistant genes of superbugs offer a promising solution.

Antibiotic-Resistant Genes

Antibiotic resistance can be conferred by several mechanisms, including mutation, gene transfer, and selection of pre-existing resistant strains. Antibiotic-resistant genes are the genes that encode for the mechanisms that bacteria use to resist antibiotics. These genes can be acquired through horizontal gene transfer, which occurs when bacteria exchange genetic material. Superbugs are strains of bacteria that are resistant to multiple antibiotics, making them difficult to treat.

Vaccine Development Services Targeting Antibiotic-Resistant Genes of Superbug

Ace Infectious offers vaccine development services targeting antibiotic-resistant genes of superbugs. We offer a range of vaccine development services, including target identification, antigen selection, vaccine design, preclinical testing, and clinical trials.

  • Identification of potential antibiotic-resistant genes. Our services include identifying potential antibiotic-resistant genes using bioinformatics tools and analyzing the genomes of superbugs to identify genes that encode for antibiotic resistance mechanisms.
  • Vaccine design. We can design vaccines that target specific antibiotic-resistant genes or multiple antibiotic-resistant genes, using DNA vaccines, protein subunit vaccines, and viral vector vaccines.
  • Vaccine production and testing. We use various production platforms to produce vaccines, such as bacterial expression systems, yeast expression systems, and mammalian expression systems. We also conduct extensive testing to ensure the safety and efficacy of the vaccines, including preclinical studies on animal models.

Potential Antibiotic-Resistant Genes Targets

We offer some different antibiotic-resistant genes present in superbugs, and these can vary depending on the species of bacteria. Some of the most common antibiotic-resistant genes include:

  • Beta-lactamase genes
  • Aminoglycoside-modifying enzyme genes
  • Tet genes
  • Macrolide-lincosamide-streptogramin B resistance (MLSb) genes

Technical Advantages

Ace Infectious has several technical advantages when it comes to vaccine development targeting antibiotic-resistant genes of superbugs:

  • Precision targeting - This precision targeting reduces the risk of collateral damage to beneficial bacteria.
  • High-throughput screening - We use high-throughput screening technologies to identify potential vaccine targets quickly and efficiently.
  • In silico design - We use in silico design to predict the immunogenicity of vaccine candidates, which helps to optimize vaccine design.
  • Animal models - We use animal models to test the safety and efficacy of vaccine candidates before moving on to clinical trials.

Vaccine development targeting antibiotic-resistant genes of superbugs is a promising solution to the public health threat posed by superbugs. Ace Infectious offers vaccine development services that can help you develop customized vaccines targeting the antibiotic-resistant genes of superbugs. With our expertise in vaccine development and state-of-the-art technologies and methodologies, we can help you develop effective and safe vaccines to combat antibiotic-resistant superbugs.

Contact us today to learn more about our vaccine development services and how we can help you address the challenges of superbugs.

Reference

  1. Frieri M, et al. Antibiotic resistance. Journal of Infection and Public Health, 2017, 1; 10(4):369-378.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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