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Vaccine Development Targeting Biofilms of Superbugs

In the face of the increasing threat of superbugs, Ace Infectious are committed to leveraging our expertise and cutting-edge technologies to develop effective vaccines targeting biofilms of superbugs. In our services, we will discuss our biofilm-specific vaccine design and development, as well as our novel vaccine strategies.

Biofilm-Specific Vaccine for Combating Superbugs

Biofilms are communities of microorganisms that adhere to surfaces and produce a protective extracellular matrix. They are notoriously difficult to eradicate and are a major contributor to the persistence of superbugs. Traditional antibiotics are often ineffective against biofilms, and the emergence of antibiotic-resistant bacteria has further complicated the situation.

To combat biofilm-forming superbugs, a biofilm-specific vaccine is needed. Such a vaccine would elicit an immune response that targets the biofilm matrix components, effectively disrupting the biofilm and rendering the bacteria vulnerable to antibiotics and other treatments.

Mechanism of biofilm formation in A. baumannii.Fig. 1 Mechanism of biofilm formation in A. baumannii. (Davies A H, et al., 2011)

Vaccine Design for Preventing Biofilm

The design of a biofilm-specific vaccine requires a thorough understanding of the structure and composition of biofilms. To effectively target the matrix components, the vaccine must contain antigens that mimic the structure of the matrix.

Our vaccine design experts have extensive experience in developing vaccines against a wide range of pathogens. We employ a variety of techniques to design vaccines that elicit strong and specific immune responses, such as

  • High-throughput screening
  • Bioinformatics analysis
  • Structural biology
  • Epitope mapping
  • Protein engineering
  • Adjuvant selection

Vaccine Development Services Targeting Biofilms of Superbugs

We offer a comprehensive range of vaccine development services, including antigen production, formulation development, and preclinical testing. Our services include:

  • Biofilm-specific target identification. We use a range of techniques to identify targets specific to biofilm-associated superbugs.
  • Vaccine design. Our team designs vaccines that target biofilm-associated superbugs based on a deep understanding of the biology of biofilms. Our formulation experts can develop a range of vaccine formulations such as subunit vaccines, virus-like particles and conjugate vaccines to optimize the immunogenicity and stability of the vaccine.
  • Vaccine production. We produce high quality antigens suitable for vaccine development and offer a range of vaccine production services, including bacterial fermentation, protein expression, and viral vector production.
  • Preclinical testing. Our preclinical testing services include in vitro and in vivo assays to evaluate the safety and efficacy of the vaccine.

Our Development Strengths

  • We have a team of scientists experienced in vaccine development and a high development success rate. And we are committed to working closely with our customers to ensure that our solutions meet their needs.
  • Our team uses the most advanced facilities and technologies to support our vaccine development work.

Ace Infectious' biofilm-specific vaccine design and development services, as well as our novel vaccine strategies, offer a promising avenue for combating superbugs and improving public health. Contact us today to learn more about our vaccine development services and how we can help you address the challenges of superbugs.

References

  1. Upmanyu K, et al. Factors mediating Acinetobacter baumannii biofilm formation: Opportunities for developing therapeutics. Current Research in Microbial Sciences, 2022: 100131.
  2. Martinez-Gutierrez F, et al. Anti-biofilm activity of silver nanoparticles against different microorganisms. Biofouling, 2013;29(6):651-660.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
Get in touch with our team immediately.